SeMoVi - May 17th, 2006 — BioSyL - Réseau de Biologie Systémique de l'Université de Lyon

14h00 - 15h00	Peter Uetz, Institute of toxicology and Genetics, Karlsruhe More information on the Peter Uetz website
15h00 - 15h30	Pause café
15h30 - 16h30	Antoine Coulon, LIRIS, INSA de Lyon Multi Agent systems for modeling nucleolus disruption during Herpes Simplex Virus infection Nancie Reymond, UMPA, ENS de Lyon Mathematical modelling of apoptosis
16h30 - 17h00	Discussion générale

Peter Uetz, Institute of toxicology and Genetics, Karlsruhe

Comprehensive yeast-two-hybrid analysis of intraviral protein interactions in 5 members of the herpesvirus family, Kaposi Sarcoma associated Herpesvirus (KSHV), Varicella Zoster Virus (VZV), Cytomegalovirus (CMV), Epstein-Barr-Virus (EBV), and Herpes Simplex Virus (HSV1), revealed between ~100 and ~250 interactions each. Viral protein interaction networks resemble single, highly coupled modules, whereas cellular networks are organized in separate functional submodules. Predicted and experimentally verified interactions between KSHV and human proteins were used to connect the viral interactomes into a prototypical human interactome to simulate infection. The analysis of the combined system showed that the viral network adopts cellular network features, and that protein networks of herpesviruses and possibly other intracellular pathogens have distinguishing topologies. When the various virus networks were compared, there are surprising differences although a number of interactions are also conserved. Structural analysis shows how interactions among these viruses evolve, thus changing their biology and pathology.

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SeMoVi - May 17th, 2006