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SLEEP

Disciplines Biology
Research fields Neurobiology, Physiology, Transcriptomics, Signal processing
Supporting organisms CNRS, UCBL, Inserm
Geographical location Centre hospitalier Vinatier, Neurocampus
Lab CRNL
Team leader Pierre-Hervé Luppi and Christelle Peyron
Webpage https://crnl.univ-lyon1.fr/index.php/en/Research/CRNL-teams-2016-2020/17
 

 

Sleep is a vital and complex behaviour identified in all animals. Based on studies on cats and humans conducted in the 1950’s, sleep was separated into two distinct states: slow wave sleep and paradoxical sleep. Slow wave sleep is characterized by a decrease of all physiological processes (i.e. heart rate, breathing rate, locomotion, body temperature) associated to high amplitude, slow frequency waves in the electroencephalogram (EEG). PS is defined by a wake-like activated EEG and rapid eye movements contrasting with generalized muscle atonia and inactivity.

 

The main objectives of the SLEEP team are to study:

1)      the basic mechanisms generating sleep

2)      The functions of sleep

3)      the evolution of sleep states by looking at the phenotypic variations of sleep across key species, chosen because of their specific phylogenetic position, ecology and physiology.

4)      the pathological processes at the origin of deleterious sleep pathologies (i.e. Narcolepsy, REM sleep behavior disorders …).

 

To reach these objectives, we use a multidisciplinary and integrated approach (LFPs, physiological and behavioural recordings, functional neuroanatomy combined with unit recordings and local pharmacology, opto- and pharmacogenetics, multiunit multisites recordings, cell profiling …)