SeMoVi - September 19th, 2007 — BioSyL - Réseau de Biologie Systémique de l'Université de Lyon

14h00 - 15h00	Bas Kooijman, Vrije Universiteit, Amsterdam Dynamic Energy Budget theory for metabolic organisation and its applications
15h00 - 15h30	Pause café
15h30 - 16h30	James Devillers, CTIS QSAR modeling in (eco)toxicology Elise Billoir, LBBE On the use of Bayesian Inference in Ecotoxicology
16h30 - 17h00	Discussion générale

Bas Kooijman, Vrije Universiteit, Amsterdam
Dynamic Energy Budget theory for metabolic organisation and its applications

Metabolic organization of individual organisms is basic to life. It seems to follow simple quantitative rules that can be understood from basic physical chemical principles. These rules quantify how individuals acquire and utilize energy and nutrients, while cycling through their life stages. Dynamic Energy Budget (DEB) theory identifies the most basic rules, and links them together in a consistent framework. The DEB theory applies to all species of organisms (unicellular as well as multicellular ones) and links various levels of biological organization; this multi-level approach is considered to be essential for the understanding of life processes. Many popular empirical models turn out to be special cases of the standard DEB model, or very close numerical approximations. The lecture will discuss some recent progress in

formalisation of the theory
evolutionary aspects of metabolic organisation
parameter estimation
applications in ecotoxicity and biotechnology

More information about research on DEB theory can be found at http://www.bio.vu.nl/thb/deb/
A general introductory paper to the DEB theory can be found athttp://www.bio.vu.nl/thb/research/bib/Kooy2001.html

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SeMoVi - September 19th, 2007