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SeMoVi - May 17th, 2006

14h00 - 15h00

Peter Uetz, Institute of toxicology and Genetics, Karlsruhe
More information on the Peter Uetz website

15h00 - 15h30 Pause café
15h30 - 16h30

Antoine Coulon, LIRIS, INSA de Lyon
Multi Agent systems for modeling nucleolus disruption during Herpes Simplex Virus infection

Nancie Reymond, UMPA, ENS de Lyon
Mathematical modelling of apoptosis

16h30 - 17h00 Discussion générale


Peter Uetz, Institute of toxicology and Genetics, Karlsruhe

Comprehensive yeast-two-hybrid analysis of intraviral protein interactions in 5 members of the herpesvirus family, Kaposi Sarcoma associated Herpesvirus (KSHV), Varicella Zoster Virus (VZV), Cytomegalovirus (CMV), Epstein-Barr-Virus (EBV), and Herpes Simplex Virus (HSV1), revealed between ~100 and ~250 interactions each. Viral protein interaction networks resemble single, highly coupled modules, whereas cellular networks are organized in separate functional submodules. Predicted and experimentally verified interactions between KSHV and human proteins were used to connect the viral interactomes into a prototypical human interactome to simulate infection. The analysis of the combined system showed that the viral network adopts cellular network features, and that protein networks of herpesviruses and possibly other intracellular pathogens have distinguishing topologies. When the various virus networks were compared, there are surprising differences although a number of interactions are also conserved. Structural analysis shows how interactions among these viruses evolve, thus changing their biology and pathology.




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