Disciplines | Molecular Biology, Computational Biology |
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Research fields | Protein-protein interactions, Conformational changes, HSF1 |
Supporting organisms | ENS Lyon, UCBL, CNRS |
Geographical location | Lyon (ENS Charles mérieux Campus) |
Lab | |
Team leader | Martin SPICHTY |
Webpage | http://www.ens-lyon.fr/LBMC/simbio/ |
We apply biomolecular computer simulations and yeast-two hybrid experiments to elucidate the structure and interactions of proteins in living cells.
We want to understand how the conformational flexibility of proteins impacts their association and regulation.
As a key application, we investigate the structural regulation of the anti-cancer target HSF1 (heat shock factor 1).
More about our Publications : click here