| Disciplines | Molecular Biology, Computational Biology |
|---|---|
| Research fields | Protein-protein interactions, Conformational changes, HSF1 |
| Supporting organisms | ENS Lyon, UCBL, CNRS |
| Geographical location | Lyon (ENS Charles mérieux Campus) |
| Lab | |
| Team leader | Martin SPICHTY |
| Webpage | http://www.ens-lyon.fr/LBMC/simbio/ |
We apply biomolecular computer simulations and yeast-two hybrid experiments to elucidate the structure and interactions of proteins in living cells.
We want to understand how the conformational flexibility of proteins impacts their association and regulation.
As a key application, we investigate the structural regulation of the anti-cancer target HSF1 (heat shock factor 1).
More about our Publications : click here
