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SIMBIO - Structure and Interactions of Molecular Biosystems

Disciplines Molecular Biology, Computational Biology
Research fields Protein-protein interactions, Conformational changes, HSF1
Supporting organisms ENS LyonUCBLCNRS
Geographical location Lyon (ENS Charles mérieux Campus)
Lab

Laboratory of cell and molecular biology (LBMC)

Team leader Martin SPICHTY
Webpage http://www.ens-lyon.fr/LBMC/simbio/

We apply biomolecular computer simulations and yeast-two hybrid experiments to elucidate the structure and interactions of proteins in living cells.

We want to understand how the conformational flexibility of proteins impacts their association and regulation.

 As a key application, we investigate the structural regulation of the anti-cancer target HSF1 (heat shock factor 1).

 

More about our Publications : click here