GrandAmphithéatre de l'INRIA Grenoble à Montbonnot
| 14h00 - 15h00 |
Aleksei Aksimentiev, University of Illinois at Urbana-Champaign |
|---|---|
| 15h00 - 15h30 | Pause café |
| 15h30 - 16h30 |
Stéphane Redon, INRIA Grenoble
Yves-Henri Sanejouand, Ecole Normale Supérieure de Lyon |
| 16h30 - 17h00 | Discussion générale |
Aleksei Aksimentiev, University of Illinois at Urbana-Champaign
Modeling silicon nanopores for detection and manipulation of single biomolecules.
The semiconductor industry routinely employs nanometer-scale fabrication to produce heterogeneous structures with feature sizes comparable to the building blocks of life: DNA and proteins. For example, the smallest feature in an intergrated circuit is the dielectric used to insulate the gate electrode from the underlying channelit is < 2 nm thick in current technology. The overwhelming success of semiconductor technology is attributable to the precise, subnanometer control it affords over the distribution of the electrostatic potential, and hence the distribution of the electrostatic force. In this talk I will describe our efforts to build devices that manipulate single biomolecules by controlling the electrostatic field in silicon nanopores and electronically sense conformational transitions in biomolecules. The talk will highlight the role of molecular modeling in the development of such tools, which, in the absence of adequate experimental instrumentation, provides unique insights into the details of microscopic interactions.
