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Postdoctoral position at Ecole Normale Supérieure / Institut Pasteur in Paris

Modeling, imaging, and manipulating neural patterning in Drosophila

Developmental patterning relies on positional cues and cell-cell communication. In the

development of Drosophila sensory organs, these are thought to operate in two distinct

steps: prepattern factors drive localized expression of proneural genes, then Notchmediated

lateral inhibition singles out neural precursors.

At odds with this paradigm, our recent results (unpublished) reveal a role for selforganization

in the emergence of proneural patterns: Notch signaling organizes a

sequence of proneural stripes that resolve into regular rows of sensory bristles on the

fly thorax. Our goal now is to better characterize the dynamics of this process, and to

explore the relevance of self-organized Notch dynamics in other developmental

contexts.

The objective of this project is to combine live imaging, optogenetics, and modeling to

characterize the dynamics of Notch signaling and neural precursor selection in the

Drosophila epidermis. Together with genetic perturbation experiments, this will inform

a quantitative description that explicitly connects the molecular scale, cellular dynamics,

and the logic of tissue patterning.

 

 

This 3-year position is funded by an ANR grant to work as a joint post-doc between the

teams of F. Corson (ENS) and F. Schweisguth (Institut Pasteur). The successful candidate

will perform image acquisition/analysis and modeling. Applicants should have a strong

background in mathematics/physics/modeling and a clear scientific interest for biology.

Previous experience in an experimental lab is desirable.

 

Contacts

Francis Corson

Laboratoire de Physique Statistique

Ecole Normale Supérieure

24 rue Lhomond

75005 Paris

 

corson@lps.ens.fr

lps.ens.fr/~corson

 

François Schweisguth

Institut Pasteur

25 rue du Dr Roux

75015 Paris

 

fschweis@pasteur.fr

research.pasteur.fr/en/team/drosophiladevelopmental-genetics/